Treatment of localized vitiligo with targeted broadband UVB

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Treatment of localized vitiligo with targeted broadband UVB

Postby Nick Balgowan » Sun Nov 12, 2006 11:34 pm

Photodermatol Photoimmunol Photomed. 2006 Jun;22(3):133-6. Links

Treatment of localized vitiligo with targeted broadband UVB phototherapy: a pilot study.

Asawanonda P, Charoenlap M, Korkij W.
Division of Dermatology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand.

BACKGROUND: Narrowband ultraviolet B (UVB) phototherapy and 308 nm excimer laser have produced encouraging therapeutic results for vitiligo. Repigmentation of various degrees was obtained in different studies. Materials and methods: Twenty-nine vitiliginous lesions from six patients were treated with targeted, broadband UV-B phototherapy. UV fluences were started at 50% of the minimal erythema dose, then increased gradually. Treatments were carried out twice weekly for 12 weeks. RESULTS: Some degree of repigmentation occurred in all subjects. Responses varied among the different anatomic locations, with acral lesions achieving the least improvement. Onset of repigmentation was as early as 3 weeks of treatment in some subjects. Treatments were well tolerated, with only minimal erythema and hyperpigmentation. LIMITATIONS: This study was carried out in a smaller number of patients with skin types III and IV. The irradiation device was a broadband UVB device, and thus the results may not be similar to those obtained from a more monochromatic system such as an excimer laser. CONCLUSIONS: Targeted broadband UVB is an efficacious and safe modality for the treatment of localized vitiligo.

PMID: 16719866 [PubMed - indexed for MEDLINE]
Nick Balgowan.
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